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  3. WASL
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Early-onset Parkinson disease

Gene: WASL

Red List (low evidence)
WASL (Wiskott-Aldrich syndrome like)
EnsemblGeneIds (GRCh38): ENSG00000106299
EnsemblGeneIds (GRCh37): ENSG00000106299
OMIM: 605056, Gene2Phenotype
WASL is in 2 panels

2 reviews

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Single family reported, where bi-allelic variants segregated with PD in three affected individuals.
Created: 26 Jul 2022, 3:23 a.m. | Last Modified: 26 Jul 2022, 3:23 a.m.
Panel Version: 0.227

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Parkinson's disease, MONDO:0005180, WASL-related

Created: 26 Jul 2022, 3:23 a.m.
Last Modified: 26 Jul 2022, 3:23 a.m.
Panel version: 0.227

SHEKEEB MOHAMMAD (Children's Hospital at Westmead)

Green List (high evidence)

Sources: Literature
Created: 22 Jul 2022, 6:46 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Early onset parkinsonism

Publications

Created: 22 Jul 2022, 6:46 a.m.

Panel version: 0.215

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
Phenotypes
  • Parkinson's disease, MONDO:0005180, WASL-related
OMIM
605056
Clinvar variants
Variants in WASL
Penetrance
None
Publications
Panels with this gene

History Filter Activity

26 Jul 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: wasl has been classified as Red List (Low Evidence).

26 Jul 2022, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: WASL were changed from Early onset parkinsonism to Parkinson's disease, MONDO:0005180, WASL-related

26 Jul 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: wasl has been classified as Red List (Low Evidence).

22 Jul 2022, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

SHEKEEB MOHAMMAD (Children's Hospital at Westmead)

gene: WASL was added gene: WASL was added to Early-onset Parkinson disease. Sources: Literature Mode of inheritance for gene: WASL was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: WASL were set to PMID: 33571872 Phenotypes for gene: WASL were set to Early onset parkinsonism Review for gene: WASL was set to GREEN