1. Panels
  2. Early-onset Parkinson disease
  3. VPS35
Regions in panel
Prev Next

Early-onset Parkinson disease

Gene: VPS35

Green List (high evidence)
VPS35 (VPS35, retromer complex component)
EnsemblGeneIds (GRCh38): ENSG00000069329
EnsemblGeneIds (GRCh37): ENSG00000069329
OMIM: 601501, Gene2Phenotype
VPS35 is in 3 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Classified as DEFINITIVE by ClinGen.
Created: 19 Mar 2022, 2:25 a.m. | Last Modified: 19 Mar 2022, 2:25 a.m.
Panel Version: 0.120

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Parkinson disease 17, MIM# 614203

Publications

Created: 19 Mar 2022, 2:25 a.m.
Last Modified: 19 Mar 2022, 2:25 a.m.
Panel version: 0.120

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Melbourne Genomics Health Alliance Complex Neurology Flagship
  • Victorian Clinical Genetics Services
Phenotypes
  • Parkinson disease 17, MIM# 614203
OMIM
601501
Clinvar variants
Variants in VPS35
Penetrance
None
Publications
Panels with this gene

History Filter Activity

19 Mar 2022, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: vps35 has been classified as Green List (High Evidence).

19 Mar 2022, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: VPS35 were changed from to Parkinson disease 17, MIM# 614203

19 Mar 2022, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: VPS35 were set to

19 Mar 2022, Gel status: 3

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: VPS35 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: VPS35 was added gene: VPS35 was added to Early onset Parkinson disease_MelbourneGenomics_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Complex Neurology Flagship Mode of inheritance for gene: VPS35 was set to Unknown