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  2. Intellectual disability syndromic and non-syndromic
  3. ZNF292
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Intellectual disability syndromic and non-syndromic

Gene: ZNF292

Green List (high evidence)
ZNF292 (zinc finger protein 292)
EnsemblGeneIds (GRCh38): ENSG00000188994
EnsemblGeneIds (GRCh37): ENSG00000188994
OMIM: 616213, Gene2Phenotype
ZNF292 is in 2 panels

3 reviews

Michelle Torres (Victorian Clinical Genetics Services)

Green List (high evidence)

Just updated the OMIM phenotype: Intellectual developmental disorder, autosomal dominant 64, MIM#619188 (there was a typo in the previous review).
Created: 15 May 2023, 2:54 a.m. | Last Modified: 15 May 2023, 2:54 a.m.
Panel Version: 0.5228

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Intellectual developmental disorder, autosomal dominant 64, MIM#619188

Created: 15 May 2023, 2:54 a.m.
Last Modified: 15 May 2023, 2:54 a.m.
Panel version: 0.5228

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Intellectual developmental disorder, autosomal dominant 63, MIM# 619188

Created: 14 Dec 2019, 3:02 a.m.
Last Modified: 14 Dec 2019, 3:02 a.m.
Panel version: 0.3458

Chirag Patel (Genetic Health Queensland)

Green List (high evidence)

28 families with spectrum of neurodevelopmental features (including ID, ASD, and ADHD) due to de novo ZNF292 variants (1 family inherited). No functional evidence of specific variants, but ZNF292 is highly expressed in the developing human brain.
Sources: Literature
Created: 11 Dec 2019, 3:24 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
no OMIM number yet

Publications

Created: 11 Dec 2019, 3:24 a.m.

Panel version: 0.1273

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Intellectual developmental disorder, autosomal dominant 64 MIM#619188
OMIM
616213
Clinvar variants
Variants in ZNF292
Penetrance
None
Publications
Panels with this gene

History Filter Activity

25 Jun 2024, Gel status: 3

Set Phenotypes

Ain Roesley (Victorian Clinical Genetics Services)

Phenotypes for gene: ZNF292 were changed from Intellectual developmental disorder, autosomal dominant 63, MIM# 619188; Intellectual disability; autism; ADHD to Intellectual developmental disorder, autosomal dominant 64 MIM#619188

22 Feb 2021, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: ZNF292 were changed from Intellectual disability; autism; ADHD to Intellectual developmental disorder, autosomal dominant 63, MIM# 619188; Intellectual disability; autism; ADHD

14 Dec 2019, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: znf292 has been classified as Green List (High Evidence).

14 Dec 2019, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: ZNF292 were changed from no OMIM number yet to Intellectual disability; autism; ADHD

11 Dec 2019, Gel status: 3

Entity classified by Genomics England curator

Chirag Patel (Genetic Health Queensland)

Gene: znf292 has been classified as Green List (High Evidence).

11 Dec 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Chirag Patel (Genetic Health Queensland)

gene: ZNF292 was added gene: ZNF292 was added to Intellectual disability, syndromic and non-syndromic_GHQ_VCGS. Sources: Literature Mode of inheritance for gene: ZNF292 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: ZNF292 were set to PMID: 31723249 Phenotypes for gene: ZNF292 were set to no OMIM number yet Review for gene: ZNF292 was set to GREEN