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Intellectual disability syndromic and non-syndromic

Gene: RNF135

Red List (low evidence)

RNF135 (ring finger protein 135)
EnsemblGeneIds (GRCh38): ENSG00000181481
EnsemblGeneIds (GRCh37): ENSG00000181481
OMIM: 611358, Gene2Phenotype
RNF135 is in 5 panels

2 reviews

Chirag Patel (Genetic Health Queensland)

Comment on list classification: d/w Z.Stark - see review
Created: 5 Dec 2019, 3:58 a.m. | Last Modified: 5 Dec 2019, 3:58 a.m.
Panel Version: 0.473

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Some early data on possible association of particular SNPs with autism/neurodevelopmental phenotypes, more recent data refuting this association.
Created: 20 Nov 2019, 3:47 a.m. | Last Modified: 20 Nov 2019, 3:47 a.m.
Panel Version: 0.8

Publications

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • Genetic Health Queensland
  • Victorian Clinical Genetics Services
OMIM
611358
Clinvar variants
Variants in RNF135
Penetrance
None
Panels with this gene

History Filter Activity

10 Dec 2019, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: rnf135 has been classified as Red List (Low Evidence).

5 Dec 2019, Gel status: 1

Entity classified by Genomics England curator

Chirag Patel (Genetic Health Queensland)

Gene: rnf135 has been classified as Red List (Low Evidence).

22 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: RNF135 was added gene: RNF135 was added to Intellectual disability, syndromic and non-syndromic_GHQ. Sources: Expert Review Green,Genetic Health Queensland Mode of inheritance for gene: RNF135 was set to Unknown