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Intellectual disability syndromic and non-syndromic

Gene: ORC6

Red List (low evidence)

ORC6 (origin recognition complex subunit 6)
EnsemblGeneIds (GRCh38): ENSG00000091651
EnsemblGeneIds (GRCh37): ENSG00000091651
OMIM: 607213, Gene2Phenotype
ORC6 is in 10 panels

1 review

Chirag Patel (Genetic Health Queensland)

Red List (low evidence)

ID not prominent feature of this syndrome.
Created: 4 Dec 2019, 11:43 p.m. | Last Modified: 4 Dec 2019, 11:43 p.m.
Panel Version: 0.397

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Meier-Gorlin syndrome 3; OMIM #613803

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • Expert list
Phenotypes
  • Meier-Gorlin syndrome 3
  • OMIM #613803
OMIM
607213
Clinvar variants
Variants in ORC6
Penetrance
None
Panels with this gene

History Filter Activity

5 Jan 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: orc6 has been classified as Red List (Low Evidence).

4 Dec 2019, Gel status: 1

Entity classified by Genomics England curator

Chirag Patel (Genetic Health Queensland)

Gene: orc6 has been classified as Red List (Low Evidence).

4 Dec 2019, Gel status: 3

Removed Source, Added New Source, Set mode of inheritance, Set Phenotypes

Chirag Patel (Genetic Health Queensland)

Source Genetic Health Queensland was removed from ORC6. Source Expert list was added to ORC6. Mode of inheritance for gene ORC6 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: ORC6 were changed from to Meier-Gorlin syndrome 3; OMIM #613803

22 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: ORC6 was added gene: ORC6 was added to Intellectual disability, syndromic and non-syndromic_GHQ. Sources: Expert Review Green,Genetic Health Queensland Mode of inheritance for gene: ORC6 was set to Unknown