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Intellectual disability syndromic and non-syndromic

Gene: MRAS

Green List (high evidence)

MRAS (muscle RAS oncogene homolog)
EnsemblGeneIds (GRCh38): ENSG00000158186
EnsemblGeneIds (GRCh37): ENSG00000158186
OMIM: 608435, Gene2Phenotype
MRAS is in 6 panels

1 review

Krithika Murali (Victorian Clinical Genetics Services)

Green List (high evidence)

Developmental delay is a phenotypic feature
Sources: Literature
Created: 10 Sep 2024, 6:03 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Noonan syndrome 11 - MIM#618499

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Noonan syndrome 11 - MIM#618499
OMIM
608435
Clinvar variants
Variants in MRAS
Penetrance
None
Panels with this gene

History Filter Activity

10 Sep 2024, Gel status: 3

Set mode of inheritance

Krithika Murali (Victorian Clinical Genetics Services)

Mode of inheritance for gene: MRAS was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

10 Sep 2024, Gel status: 3

Entity classified by Genomics England curator

Krithika Murali (Victorian Clinical Genetics Services)

Gene: mras has been classified as Green List (High Evidence).

10 Sep 2024, Gel status: 1

Entity classified by Genomics England curator

Krithika Murali (Victorian Clinical Genetics Services)

Gene: mras has been classified as Red List (Low Evidence).

10 Sep 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Krithika Murali (Victorian Clinical Genetics Services)

gene: MRAS was added gene: MRAS was added to Intellectual disability syndromic and non-syndromic. Sources: Literature Mode of inheritance for gene: MRAS was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: MRAS were set to Noonan syndrome 11 - MIM#618499 Review for gene: MRAS was set to GREEN