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Intellectual disability syndromic and non-syndromic

Gene: LINS1

Green List (high evidence)

LINS1 (lines homolog 1)
EnsemblGeneIds (GRCh38): ENSG00000140471
EnsemblGeneIds (GRCh37): ENSG00000140471
OMIM: 610350, Gene2Phenotype
LINS1 is in 5 panels

1 review

Alison Yeung (Victorian Clinical Genetics Services)

Green List (high evidence)

>3 unrelated families with bilallelic variants reported
Created: 2 May 2022, 2:05 a.m. | Last Modified: 2 May 2022, 2:05 a.m.
Panel Version: 0.4713

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
ntellectual developmental disorder, autosomal recessive 27, MIM# 614340

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Genetic Health Queensland
Phenotypes
  • Intellectual developmental disorder, autosomal recessive 27, MIM# 614340
OMIM
610350
Clinvar variants
Variants in LINS1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

2 May 2022, Gel status: 3

Set Phenotypes

Alison Yeung (Victorian Clinical Genetics Services)

Phenotypes for gene: LINS1 were changed from Intellectual developmental disorder, autosomal recessive 27, MIM# 614340 to Intellectual developmental disorder, autosomal recessive 27, MIM# 614340

2 May 2022, Gel status: 3

Set Phenotypes

Alison Yeung (Victorian Clinical Genetics Services)

Phenotypes for gene: LINS1 were changed from to Intellectual developmental disorder, autosomal recessive 27, MIM# 614340

2 May 2022, Gel status: 3

Entity classified by Genomics England curator

Alison Yeung (Victorian Clinical Genetics Services)

Gene: lins1 has been classified as Green List (High Evidence).

2 May 2022, Gel status: 3

Set publications

Alison Yeung (Victorian Clinical Genetics Services)

Publications for gene: LINS1 were set to

2 May 2022, Gel status: 3

Set mode of inheritance

Alison Yeung (Victorian Clinical Genetics Services)

Mode of inheritance for gene: LINS1 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

22 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: LINS1 was added gene: LINS1 was added to Intellectual disability, syndromic and non-syndromic_GHQ. Sources: Expert Review Green,Genetic Health Queensland Mode of inheritance for gene: LINS1 was set to Unknown