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  2. Motor Neurone Disease
  3. LGALSL
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Motor Neurone Disease

Gene: LGALSL

Amber List (moderate evidence)
LGALSL (galectin like)
EnsemblGeneIds (GRCh38): ENSG00000119862
EnsemblGeneIds (GRCh37): ENSG00000119862
LGALSL is in 1 panel

1 review

Bryony Thompson (Royal Melbourne Hospital)

I don't know

Limited gene-disease validity assessment by ClinGen ALS spectrum disorder GCEP - 14/02/2023. Significant enrichment in a cohort of 3,239 ALS cases compared to 11,808 controls - OR = 14.63; P = 2.29e-6.
Sources: ClinGen
Created: 22 Jun 2023, 1:41 a.m.

Mode of inheritance
Unknown

Phenotypes
amyotrophic lateral sclerosis MONDO:0004976

Publications

Created: 22 Jun 2023, 1:41 a.m.

Panel version: 0.186

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Amber
  • ClinGen
Phenotypes
  • amyotrophic lateral sclerosis MONDO:0004976
Clinvar variants
Variants in LGALSL
Penetrance
None
Publications
Panels with this gene

History Filter Activity

22 Jun 2023, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: lgalsl has been classified as Amber List (Moderate Evidence).

22 Jun 2023, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: lgalsl has been classified as Amber List (Moderate Evidence).

22 Jun 2023, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: LGALSL was added gene: LGALSL was added to Motor Neurone Disease. Sources: ClinGen Mode of inheritance for gene: LGALSL was set to Unknown Publications for gene: LGALSL were set to 30940688 Phenotypes for gene: LGALSL were set to amyotrophic lateral sclerosis MONDO:0004976 Review for gene: LGALSL was set to AMBER