Early-onset Dementia
Gene: NR4A2
NR4A2 (nuclear receptor subfamily 4 group A member 2)
EnsemblGeneIds (GRCh38): ENSG00000153234
EnsemblGeneIds (GRCh37): ENSG00000153234
OMIM: 601828, Gene2Phenotype
NR4A2 is in 7 panels
EnsemblGeneIds (GRCh38): ENSG00000153234
EnsemblGeneIds (GRCh37): ENSG00000153234
OMIM: 601828, Gene2Phenotype
NR4A2 is in 7 panels
1 review
Bryony Thompson (Royal Melbourne Hospital)
Dopamine neuron agenesis occurs in Nurr1 deficient mice. No evidence that rare variants in this gene cause dementia. Was initially reported as a Parkinson disease susceptibility loci, but has not been replicated in large studies.Created: 6 Feb 2020, 5:27 a.m. | Last Modified: 6 Feb 2020, 5:27 a.m.
Panel Version: 0.6
Mode of inheritance
Unknown
Publications
Details
- Mode of Inheritance
- Unknown
- Sources
-
- Expert Review Red
- Melbourne Genomics Health Alliance Complex Neurology Flagship
- Victorian Clinical Genetics Services
- OMIM
- 601828
- Clinvar variants
- Variants in NR4A2
- Penetrance
- None
- Panels with this gene
History Filter Activity
21 Aug 2023, Gel status: 1
Entity classified by Genomics England curator
Bryony Thompson (Royal Melbourne Hospital)Gene: nr4a2 has been classified as Red List (Low Evidence).
6 Feb 2020, Gel status: 1
Entity classified by Genomics England curator
Bryony Thompson (Royal Melbourne Hospital)Gene: nr4a2 has been classified as Red List (Low Evidence).
17 Nov 2019, Gel status: 3
Created, Added New Source, Set mode of inheritance
Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)gene: NR4A2 was added gene: NR4A2 was added to Early-onset Dementia_MGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Complex Neurology Flagship Mode of inheritance for gene: NR4A2 was set to Unknown