Early-onset Dementia
Gene: LRRK2

LRRK2 (leucine rich repeat kinase 2)
EnsemblGeneIds (GRCh38): ENSG00000188906
EnsemblGeneIds (GRCh37): ENSG00000188906
OMIM: 609007, Gene2Phenotype
LRRK2 is in 6 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

Green List (high evidence)

Cognitive impairment reported in a mouse model and dementia or cognitive decline reported in at least 3 cases.
Created: 6 Feb 2020, 4:56 a.m. | Last Modified: 6 Feb 2020, 4:56 a.m.

Panel Version: 0.6

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Parkinson disease 8 MIM#607060

Publications

Created: 6 Feb 2020, 4:56 a.m.
Last Modified: 6 Feb 2020, 4:56 a.m.
Panel version: 0.6

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

Melbourne Genomics Health Alliance Complex Neurology Flagship
Victorian Clinical Genetics Services
Expert Review Green

OMIM

609007

Clinvar variants

Variants in LRRK2

Penetrance

None

Panels with this gene

History Filter Activity

6 Feb 2020, Gel status: 3

Set mode of inheritance

Bryony Thompson (Royal Melbourne Hospital)

Mode of inheritance for gene: LRRK2 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: LRRK2 was added gene: LRRK2 was added to Early-onset Dementia_MGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Complex Neurology Flagship Mode of inheritance for gene: LRRK2 was set to Unknown

Early-onset Dementia Gene: LRRK2