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  3. GSN
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Early-onset Dementia

Gene: GSN

Red List (low evidence)
GSN (gelsolin)
EnsemblGeneIds (GRCh38): ENSG00000148180
EnsemblGeneIds (GRCh37): ENSG00000148180
OMIM: 137350, Gene2Phenotype
GSN is in 7 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

Red List (low evidence)

I could not find any evidence of a gene-disease association with dementia. Hereditary motor and sensory neuropathy is reported as the neurological phenotype.
Sources: Expert list
Created: 19 Aug 2020, 6:50 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Amyloidosis, Finnish type MIM#105120

Created: 19 Aug 2020, 6:50 a.m.

Panel version: 0.60

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Red
  • Expert list
Phenotypes
  • Amyloidosis, Finnish type MIM#105120
OMIM
137350
Clinvar variants
Variants in GSN
Penetrance
None
Panels with this gene

History Filter Activity

19 Aug 2020, Gel status: 1

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: gsn has been classified as Red List (Low Evidence).

19 Aug 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: GSN was added gene: GSN was added to Early-onset Dementia. Sources: Expert list Mode of inheritance for gene: GSN was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: GSN were set to Amyloidosis, Finnish type MIM#105120 Review for gene: GSN was set to RED