Early-onset Dementia

Gene: ANG

Red List (low evidence)

ANG (angiogenin)
EnsemblGeneIds (GRCh38): ENSG00000214274
EnsemblGeneIds (GRCh37): ENSG00000214274
OMIM: 105850, Gene2Phenotype
ANG is in 4 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

Red List (low evidence)

Comment on list classification: Not a prominent ALS-FTD phenotype
Created: 6 Feb 2020, 8:54 a.m. | Last Modified: 6 Feb 2020, 8:54 a.m.
Panel Version: 0.18
Only one report of dementia in one case in a large familial ALS pedigree. Dementia or cognitive decline is not a prominent feature of the condition.
Created: 5 Feb 2020, 6:27 a.m. | Last Modified: 5 Feb 2020, 6:27 a.m.
Panel Version: 0.1

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Amyotrophic lateral sclerosis 9 MIM#611895

Publications

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • Melbourne Genomics Health Alliance Complex Neurology Flagship
  • Victorian Clinical Genetics Services
OMIM
105850
Clinvar variants
Variants in ANG
Penetrance
None
Panels with this gene

History Filter Activity

21 Aug 2023, Gel status: 1

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: ang has been classified as Red List (Low Evidence).

6 Feb 2020, Gel status: 1

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: ang has been classified as Red List (Low Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: ANG was added gene: ANG was added to Early-onset Dementia_MGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Complex Neurology Flagship Mode of inheritance for gene: ANG was set to Unknown