Entity Name	Entity type	Gene Symbol	Sources(; separated)	Level4	Level3	Level2	Model_Of_Inheritance	Phenotypes	Omim	Orphanet	HPO	Publications	Description	Flagged	GEL_Status	UserRatings_Green_amber_red	version	ready	Mode of pathogenicity	EnsemblId(GRch37)	EnsemblId(GRch38)	HGNC	Position Chromosome	Position GRCh37 Start	Position GRCh37 End	Position GRCh38 Start	Position GRCh38 End	STR Repeated Sequence	STR Normal Repeats	STR Pathogenic Repeats	Region Haploinsufficiency Score	Region Triplosensitivity Score	Region Required Overlap Percentage	Region Variant Type	Region Verbose Name
APOE	gene	APOE	Expert Review Amber;Melbourne Genomics Health Alliance Complex Neurology Flagship;Victorian Clinical Genetics Services	Early-onset Dementia		Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Alzheimer disease 2, MIM# 104310			Cognitive impairment;HP:0100543			False	2	0;100;0	1.29	True		ENSG00000130203	ENSG00000130203	HGNC:613													
CCNF	gene	CCNF	Expert list;Expert Review Amber	Early-onset Dementia		Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Frontotemporal dementia and/or amyotrophic lateral sclerosis 5, MIM# 619141			Cognitive impairment;HP:0100543	27080313		False	2	0;100;0	1.29	True		ENSG00000162063	ENSG00000162063	HGNC:1591													
COL4A2	gene	COL4A2	Expert Review Amber;Literature	Early-onset Dementia		Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Familial porencephaly MONDO:0020496			Cognitive impairment;HP:0100543	35699195;37272523;36300346		False	2	0;100;0	1.29	True		ENSG00000134871	ENSG00000134871	HGNC:2203													
CYLD	gene	CYLD	Expert Review Amber;Literature	Early-onset Dementia		Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Frontotemporal dementia and/or amytrophic lateral sclerosis 8, MIM# 619132			Cognitive impairment;HP:0100543	32185393		False	2	0;50;50	1.29	True		ENSG00000083799	ENSG00000083799	HGNC:2584													
GBA	gene	GBA	Expert Review Amber;Melbourne Genomics Health Alliance Complex Neurology Flagship;Victorian Clinical Genetics Services	Early-onset Dementia		Neurology and neurodevelopmental disorders	Other	{Lewy body dementia, susceptibility to} (MIM# 127750)			Cognitive impairment;HP:0100543	23588557;32439597;31010158		False	2	0;100;0	1.29	True		ENSG00000177628	ENSG00000177628	HGNC:4177													
HNRNPA1	gene	HNRNPA1	Expert Review Amber;Other	Early-onset Dementia		Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Inclusion body myopathy with early-onset Paget disease without frontotemporal dementia 3 MIM#615424;Amyotrophic lateral sclerosis 20 MIM#615426			Cognitive impairment;HP:0100543	24612671;24119545;23455423		False	2	0;0;100	1.29	True		ENSG00000135486	ENSG00000135486	HGNC:5031													
HNRNPA2B1	gene	HNRNPA2B1	Expert Review Amber;Literature	Early-onset Dementia		Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2 MIM#615422			Cognitive impairment;HP:0100543	23455423;30279180;29358076;26744327;23635965		False	2	0;100;0	1.29	True		ENSG00000122566	ENSG00000122566	HGNC:5033													
KIF5A	gene	KIF5A	Expert Review Amber;Other	Early-onset Dementia		Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Amyotrophic lateral sclerosis, susceptibility to, 25 MONDO:0060670			Cognitive impairment;HP:0100543	33077544;36604770		False	2	0;100;0	1.29	True	Other	ENSG00000155980	ENSG00000155980	HGNC:6323													
MATR3	gene	MATR3	Expert Review Amber;Melbourne Genomics Health Alliance Complex Neurology Flagship;Victorian Clinical Genetics Services	Early-onset Dementia		Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Amyotrophic lateral sclerosis 21 MIM#606070;frontotemporal dementia;multisystem proteinopathy			Cognitive impairment;HP:0100543	24686783;30015619;28029397;33408686		False	2	0;100;0	1.29	True		ENSG00000015479	ENSG00000015479	HGNC:6912													
POLG	gene	POLG	Expert Review Amber;Literature	Early-onset Dementia		Neurology and neurodevelopmental disorders	BIALLELIC, autosomal or pseudoautosomal	"Mitochondrial DNA depletion syndrome 4a	MONDO:0008758"			Cognitive impairment;HP:0100543	15477547;14694057;16638794		False	2	0;100;0	1.29	True		ENSG00000140521	ENSG00000140521	HGNC:9179													
SQSTM1	gene	SQSTM1	Expert Review Amber;Melbourne Genomics Health Alliance Complex Neurology Flagship;Victorian Clinical Genetics Services	Early-onset Dementia		Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 (MIM#616437)			Cognitive impairment;HP:0100543	22084127;22972638		False	2	0;100;0	1.29	True		ENSG00000161011	ENSG00000161011	HGNC:11280													
TAF15	gene	TAF15	Expert list;Expert Review Amber	Early-onset Dementia		Neurology and neurodevelopmental disorders	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Amyotrophic lateral sclerosis;Frontotemporal dementia			Cognitive impairment;HP:0100543	28889094		False	2	0;100;0	1.29	False		ENSG00000172660	ENSG00000270647	HGNC:11547													
TIA1	gene	TIA1	Expert Review Amber;Literature	Early-onset Dementia		Neurology and neurodevelopmental disorders	Other	Multisystem proteinopathy			Cognitive impairment;HP:0100543	36861178;29599744;29457785		False	2	0;100;0	1.29	True		ENSG00000116001	ENSG00000116001	HGNC:11802