Susceptibility to Viral Infections
Gene: TNFRSF4
TNFRSF4 (TNF receptor superfamily member 4)
EnsemblGeneIds (GRCh38): ENSG00000186827
EnsemblGeneIds (GRCh37): ENSG00000186827
OMIM: 600315, Gene2Phenotype
TNFRSF4 is in 3 panels
EnsemblGeneIds (GRCh38): ENSG00000186827
EnsemblGeneIds (GRCh37): ENSG00000186827
OMIM: 600315, Gene2Phenotype
TNFRSF4 is in 3 panels
1 review
Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)
Single case report in an individual with childhood-onset Kaposi's sarcoma (susceptibility to HHV8), homozygous missense variant, plausible biological candidate but direct evidence of causality limited.
Sources: Expert listCreated: 12 Jun 2020, 8:31 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Immunodeficiency 16, MIM# 615593
Publications
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Expert Review Red
- Expert list
- Phenotypes
-
- Immunodeficiency 16, MIM# 615593
- OMIM
- 600315
- Clinvar variants
- Variants in TNFRSF4
- Penetrance
- None
- Publications
- Panels with this gene
History Filter Activity
12 Jun 2020, Gel status: 1
Entity classified by Genomics England curator
Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)Gene: tnfrsf4 has been classified as Red List (Low Evidence).
12 Jun 2020, Gel status: 1
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes
Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)gene: TNFRSF4 was added gene: TNFRSF4 was added to Susceptibility to Viral Infections. Sources: Expert list Mode of inheritance for gene: TNFRSF4 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: TNFRSF4 were set to 23897980 Phenotypes for gene: TNFRSF4 were set to Immunodeficiency 16, MIM# 615593 Review for gene: TNFRSF4 was set to RED