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  2. Susceptibility to Viral Infections
  3. TLR7
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Susceptibility to Viral Infections

Gene: TLR7

Green List (high evidence)
TLR7 (toll like receptor 7)
EnsemblGeneIds (GRCh38): ENSG00000196664
EnsemblGeneIds (GRCh37): ENSG00000196664
OMIM: 300365, Gene2Phenotype
TLR7 is in 4 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Four affected individuals from two unrelated families and some functional data.
Sources: Expert list
Created: 28 Aug 2020, 10:18 a.m.

Mode of inheritance
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Phenotypes
Immunodeficiency 74, COVID19-related, X-linked, MIM# 301051

Publications

Created: 28 Aug 2020, 10:18 a.m.

Panel version: 0.67

Details

Mode of Inheritance
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Immunodeficiency 74, COVID19-related, X-linked, MIM# 301051
OMIM
300365
Clinvar variants
Variants in TLR7
Penetrance
None
Publications
Panels with this gene

History Filter Activity

7 Sep 2020, Gel status: 3

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: TLR7 was changed from BIALLELIC, autosomal or pseudoautosomal to X-LINKED: hemizygous mutation in males, biallelic mutations in females

28 Aug 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: tlr7 has been classified as Green List (High Evidence).

28 Aug 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: tlr7 has been classified as Green List (High Evidence).

28 Aug 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: TLR7 was added gene: TLR7 was added to Susceptibility to Viral Infections. Sources: Expert list Mode of inheritance for gene: TLR7 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: TLR7 were set to 32706371 Phenotypes for gene: TLR7 were set to Immunodeficiency 74, COVID19-related, X-linked, MIM# 301051 Review for gene: TLR7 was set to GREEN