Susceptibility to Viral Infections
Gene: TLR3

TLR3 (toll like receptor 3)
EnsemblGeneIds (GRCh38): ENSG00000164342
EnsemblGeneIds (GRCh37): ENSG00000164342
OMIM: 603029, Gene2Phenotype
TLR3 is in 3 panels

2 reviews

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
{Immunodeficiency 83, susceptibility to viral infections}, MIM# 613002

Created: 26 Oct 2022, 11:54 p.m.
Last Modified: 26 Oct 2022, 11:54 p.m.
Panel version: 0.103

Peter McNaughton (Queensland Children's Hospital)

Green List (high evidence)

Dominant negative inheritance
Created: 26 Oct 2022, 10:17 p.m. | Last Modified: 26 Oct 2022, 10:17 p.m.

Panel Version: 0.94

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Herpes encephalitis

Publications

PMID: 17872438
PMID: 25339207

Created: 26 Oct 2022, 10:17 p.m.
Last Modified: 26 Oct 2022, 10:17 p.m.
Panel version: 0.94

Details

Mode of Inheritance

BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Sources

Expert Review Green
Melbourne Genomics Health Alliance Immunology Flagship
Victorian Clinical Genetics Services

Phenotypes

{Immunodeficiency 83, susceptibility to viral infections}, MIM# 613002

OMIM

603029

Clinvar variants

Variants in TLR3

Penetrance

None

Publications

Panels with this gene