Susceptibility to Viral Infections
Gene: TICAM1

TICAM1 (toll like receptor adaptor molecule 1)
EnsemblGeneIds (GRCh38): ENSG00000127666
EnsemblGeneIds (GRCh37): ENSG00000127666
OMIM: 607601, Gene2Phenotype
TICAM1 is in 3 panels

2 reviews

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Two each with bi-allelic and mono-allelic variants (total of 4 patients), plus functional data.
Created: 26 Oct 2022, 10:29 p.m. | Last Modified: 26 Oct 2022, 10:29 p.m.

Panel Version: 0.101

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
{Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 6}, MIM# 614850

Publications

Created: 26 Oct 2022, 10:27 p.m.
Last Modified: 26 Oct 2022, 10:27 p.m.
Panel version: 0.101

Peter McNaughton (Queensland Children's Hospital)

2x unrelated patients with herpes predisposition with functional validation.
Created: 26 Oct 2022, 6:59 a.m. | Last Modified: 26 Oct 2022, 6:59 a.m.

Panel Version: 0.93

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
Herpes encephalitis

Publications

PMID: 22105173

Created: 26 Oct 2022, 6:59 a.m.
Last Modified: 26 Oct 2022, 6:59 a.m.
Panel version: 0.93

Details

Mode of Inheritance

BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Sources

Expert Review Green
Melbourne Genomics Health Alliance Immunology Flagship
Victorian Clinical Genetics Services

Phenotypes

{Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 6}, MIM# 614850

OMIM

607601

Clinvar variants

Variants in TICAM1

Penetrance

None

Publications

Panels with this gene