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  2. Susceptibility to Viral Infections
  3. NOS2
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Susceptibility to Viral Infections

Gene: NOS2

Red List (low evidence)
NOS2 (nitric oxide synthase 2)
EnsemblGeneIds (GRCh38): ENSG00000007171
EnsemblGeneIds (GRCh37): ENSG00000007171
OMIM: 163730, Gene2Phenotype
NOS2 is in 3 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Single individual reported with progressive, fatal CMV disease and homozygous LoF variant in NOS2.
Sources: Expert list
Created: 29 Apr 2020, 8:54 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Disseminated CMV disease

Publications

Created: 29 Apr 2020, 8:54 a.m.

Panel version: 0.52

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • Expert list
Phenotypes
  • Disseminated CMV disease
OMIM
163730
Clinvar variants
Variants in NOS2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

29 Apr 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: nos2 has been classified as Red List (Low Evidence).

29 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: NOS2 was added gene: NOS2 was added to Susceptibility to Viral Infections. Sources: Expert list Mode of inheritance for gene: NOS2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: NOS2 were set to 31995689 Phenotypes for gene: NOS2 were set to Disseminated CMV disease Review for gene: NOS2 was set to RED