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  2. Susceptibility to Viral Infections
  3. MCM10
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Susceptibility to Viral Infections

Gene: MCM10

Amber List (moderate evidence)
MCM10 (minichromosome maintenance 10 replication initiation factor)
EnsemblGeneIds (GRCh38): ENSG00000065328
EnsemblGeneIds (GRCh37): ENSG00000065328
OMIM: 609357, Gene2Phenotype
MCM10 is in 4 panels

2 reviews

Peter McNaughton (Queensland Children's Hospital)

I don't know

Further functional validation of molecular mechanism of MCM10
Created: 27 Jul 2022, 5:27 a.m. | Last Modified: 27 Jul 2022, 5:27 a.m.
Panel Version: 0.91

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Publications

Created: 27 Jul 2022, 5:27 a.m.
Last Modified: 27 Jul 2022, 5:27 a.m.
Panel version: 0.91

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Compound heterozygous variants in minichromosomal maintenance complex member 10 (MCM10) reported as a cause of NK-cell deficiency in a child with fatal susceptibility to CMV.
Sources: Literature
Created: 4 Sep 2020, 11:14 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Immunodeficiency-80 with or without congenital cardiomyopathy (IMD80), MIM#619313; Susceptibility to CMV

Publications

Created: 4 Sep 2020, 11:14 a.m.

Panel version: 0.74

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Literature
Phenotypes
  • Immunodeficiency-80 with or without congenital cardiomyopathy (IMD80), MIM#619313
  • Susceptibility to CMV
OMIM
609357
Clinvar variants
Variants in MCM10
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 Jul 2022, Gel status: 2

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: MCM10 were set to 32865517

28 Jul 2022, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: mcm10 has been classified as Amber List (Moderate Evidence).

12 May 2021, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: MCM10 were changed from Susceptibility to CMV to Immunodeficiency-80 with or without congenital cardiomyopathy (IMD80), MIM#619313; Susceptibility to CMV

4 Sep 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: mcm10 has been classified as Red List (Low Evidence).

4 Sep 2020, Gel status: 1

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: MCM10 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to BIALLELIC, autosomal or pseudoautosomal

4 Sep 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: MCM10 was added gene: MCM10 was added to Susceptibility to Viral Infections. Sources: Literature Mode of inheritance for gene: MCM10 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: MCM10 were set to 32865517 Phenotypes for gene: MCM10 were set to Susceptibility to CMV Review for gene: MCM10 was set to RED