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  3. IFNAR1
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Susceptibility to Viral Infections

Gene: IFNAR1

Green List (high evidence)
IFNAR1 (interferon alpha and beta receptor subunit 1)
EnsemblGeneIds (GRCh38): ENSG00000142166
EnsemblGeneIds (GRCh37): ENSG00000142166
OMIM: 107450, Gene2Phenotype
IFNAR1 is in 3 panels

2 reviews

Peter McNaughton (Queensland Children's Hospital)

Green List (high evidence)

Seven children from five unrelated kindreds
Created: 11 Jul 2022, 4:10 a.m. | Last Modified: 11 Jul 2022, 4:10 a.m.
Panel Version: 0.83

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Severe Viral disease

Publications

Created: 11 Jul 2022, 4:10 a.m.
Last Modified: 11 Jul 2022, 4:10 a.m.
Panel version: 0.83

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

I don't know

Two unrelated individuals reported with bi-allelic LoF variants, some functional data.
Sources: Expert list
Created: 5 Apr 2020, 7:45 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Severe disease caused by Yellow Fever vaccine and Measles vaccine

Publications

Created: 5 Apr 2020, 7:45 a.m.

Panel version: 0.11

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Immunodeficiency 106, susceptibility to viral infections, MIM# 619935
  • Severe disease caused by Yellow Fever vaccine and Measles vaccine
OMIM
107450
Clinvar variants
Variants in IFNAR1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

13 Jul 2022, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: IFNAR1 were changed from Severe disease caused by Yellow Fever vaccine and Measles vaccine to Immunodeficiency 106, susceptibility to viral infections, MIM# 619935; Severe disease caused by Yellow Fever vaccine and Measles vaccine

13 Jul 2022, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ifnar1 has been classified as Green List (High Evidence).

5 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ifnar1 has been classified as Amber List (Moderate Evidence).

5 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ifnar1 has been classified as Amber List (Moderate Evidence).

5 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: IFNAR1 was added gene: IFNAR1 was added to Susceptibility to Viral Infections. Sources: Expert list Mode of inheritance for gene: IFNAR1 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: IFNAR1 were set to 31270247 Phenotypes for gene: IFNAR1 were set to Severe disease caused by Yellow Fever vaccine and Measles vaccine Review for gene: IFNAR1 was set to AMBER