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Susceptibility to Viral Infections
Gene: CD4

CD4 (CD4 molecule)
EnsemblGeneIds (GRCh38): ENSG00000010610
EnsemblGeneIds (GRCh37): ENSG00000010610
OMIM: 186940, Gene2Phenotype
CD4 is in 2 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Two individuals reported, functional data.
Sources: Literature
Created: 1 May 2020, 3:39 a.m. | Last Modified: 27 Mar 2021, 3:02 a.m.

Panel Version: 0.69

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Immunodeficiency 79, MIM# 619238; Absence of CD4+ T cells; exuberant, relapsing, treatment-refractory warts

Publications

Created: 1 May 2020, 3:39 a.m.
Last Modified: 27 Mar 2021, 3:02 a.m.
Panel version: 0.69

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

Expert Review Green
Literature

Phenotypes

Immunodeficiency 79, MIM# 619238
Absence of CD4+ T cells
exuberant, relapsing, treatment-refractory warts

OMIM

Clinvar variants

Variants in CD4

Penetrance

None

Publications

Panels with this gene

History Filter Activity

27 Mar 2021, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: CD4 were changed from Absence of CD4+ T cells; exuberant, relapsing, treatment-refractory warts to Immunodeficiency 79, MIM# 619238; Absence of CD4+ T cells; exuberant, relapsing, treatment-refractory warts

27 Mar 2021, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: CD4 were set to 31781092

27 Mar 2021, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: cd4 has been classified as Green List (High Evidence).

1 May 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: cd4 has been classified as Amber List (Moderate Evidence).

1 May 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: cd4 has been classified as Amber List (Moderate Evidence).

1 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: CD4 was added gene: CD4 was added to Susceptibility to Viral Infections. Sources: Literature Mode of inheritance for gene: CD4 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: CD4 were set to 31781092 Phenotypes for gene: CD4 were set to Absence of CD4+ T cells; exuberant, relapsing, treatment-refractory warts Review for gene: CD4 was set to AMBER