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  2. Susceptibility to Viral Infections
  3. CCR5
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Susceptibility to Viral Infections

Gene: CCR5

Green List (high evidence)
CCR5 (C-C motif chemokine receptor 5 (gene/pseudogene))
EnsemblGeneIds (GRCh38): ENSG00000160791
EnsemblGeneIds (GRCh37): ENSG00000160791
OMIM: 601373, Gene2Phenotype
CCR5 is in 2 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Particular SNVs in this gene are well established as conferring resistance to certain viral infections, notably HIV.
Sources: Expert list
Created: 12 Jun 2020, 8:37 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
{Hepatitis C virus, resistance to} 609532; {HIV infection, susceptibility/resistance to}; {West nile virus, susceptibility to}MIM# 610379

Created: 12 Jun 2020, 8:37 a.m.

Panel version: 0.59

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • {Hepatitis C virus, resistance to} 609532
  • {HIV infection, susceptibility/resistance to}
  • {West nile virus, susceptibility to}MIM# 610379
OMIM
601373
Clinvar variants
Variants in CCR5
Penetrance
None
Panels with this gene

History Filter Activity

12 Jun 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ccr5 has been classified as Green List (High Evidence).

12 Jun 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ccr5 has been classified as Green List (High Evidence).

12 Jun 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: CCR5 was added gene: CCR5 was added to Susceptibility to Viral Infections. Sources: Expert list Mode of inheritance for gene: CCR5 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Phenotypes for gene: CCR5 were set to {Hepatitis C virus, resistance to} 609532; {HIV infection, susceptibility/resistance to}; {West nile virus, susceptibility to}MIM# 610379 Review for gene: CCR5 was set to GREEN