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Susceptibility to Fungal Infections
Gene: TRAF3IP2

TRAF3IP2 (TRAF3 interacting protein 2)
EnsemblGeneIds (GRCh38): ENSG00000056972
EnsemblGeneIds (GRCh37): ENSG00000056972
OMIM: 607043, Gene2Phenotype
TRAF3IP2 is in 3 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

I don't know

Two unrelated individuals reported, plausible biological candidate as TRAF3IP2 is an adaptor protein involved in downstream signalling for IL-17 receptors.
Created: 12 Apr 2020, 4:20 a.m. | Last Modified: 12 Apr 2020, 4:20 a.m.

Panel Version: 0.11

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Candidiasis, familial, 8, MIM# 615527

Publications

Created: 12 Apr 2020, 4:20 a.m.
Last Modified: 12 Apr 2020, 4:20 a.m.
Panel version: 0.11

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

Expert Review Amber
Melbourne Genomics Health Alliance Immunology Flagship
Victorian Clinical Genetics Services

Phenotypes

Candidiasis, familial, 8, MIM# 615527

OMIM

Clinvar variants

Variants in TRAF3IP2

Penetrance

None

Publications

Panels with this gene

History Filter Activity

12 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: traf3ip2 has been classified as Amber List (Moderate Evidence).

12 Apr 2020, Gel status: 2

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: TRAF3IP2 were changed from to Candidiasis, familial, 8, MIM# 615527

12 Apr 2020, Gel status: 2

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: TRAF3IP2 were set to

12 Apr 2020, Gel status: 2

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: TRAF3IP2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

12 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: traf3ip2 has been classified as Amber List (Moderate Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: TRAF3IP2 was added gene: TRAF3IP2 was added to Susceptibility to fungal infections_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship Mode of inheritance for gene: TRAF3IP2 was set to Unknown