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  2. Defects of intrinsic and innate immunity
  3. ZNFX1
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Defects of intrinsic and innate immunity

Gene: ZNFX1

Green List (high evidence)
ZNFX1 (zinc finger NFX1-type containing 1)
EnsemblGeneIds (GRCh38): ENSG00000124201
EnsemblGeneIds (GRCh37): ENSG00000124201
ZNFX1 is in 4 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

15 individuals from 8 families reported.
Sources: Literature
Created: 7 May 2021, 2:56 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Immunodeficiency 91 and hyperinflammation, MIM# 619644

Publications

Created: 7 May 2021, 2:56 a.m.

Panel version: Imported from Susceptibility to Viral Infections panel version 0.81

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
  • Expert Review Green
  • Literature
Phenotypes
  • immunodeficiency 91 and hyperinflammation MONDO:0030491
Clinvar variants
Variants in ZNFX1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

16 Dec 2024, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: znfx1 has been classified as Green List (High Evidence).

16 Dec 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: ZNFX1 was added gene: ZNFX1 was added to Defects of innate immunity. Sources: Expert list Mode of inheritance for gene: ZNFX1 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: ZNFX1 were set to 33872655 Phenotypes for gene: ZNFX1 were set to immunodeficiency 91 and hyperinflammation MONDO:0030491