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  2. Defects of intrinsic and innate immunity
  3. TICAM1
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Defects of intrinsic and innate immunity

Gene: TICAM1

Green List (high evidence)
TICAM1 (toll like receptor adaptor molecule 1)
EnsemblGeneIds (GRCh38): ENSG00000127666
EnsemblGeneIds (GRCh37): ENSG00000127666
OMIM: 607601, Gene2Phenotype
TICAM1 is in 3 panels

2 reviews

Peter McNaughton (Queensland Children's Hospital)

Green List (high evidence)

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
Herpes encephalitis

Publications

Created: 27 Oct 2022, 4:07 a.m.
Last Modified: 27 Oct 2022, 4:07 a.m.
Panel version: 0.126

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Two each with bi-allelic and mono-allelic variants (total of 4 patients), plus functional data.
Created: 26 Oct 2022, 10:29 p.m. | Last Modified: 26 Oct 2022, 10:29 p.m.
Panel Version: 0.101

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
{Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 6}, MIM# 614850

Publications

Created: 26 Oct 2022, 10:27 p.m.
Last Modified: 26 Oct 2022, 10:27 p.m.
Panel version: Imported from Susceptibility to Viral Infections panel version 0.101

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Green
  • Melbourne Genomics Health Alliance Immunology Flagship
  • Victorian Clinical Genetics Services
  • Melbourne Genomics Health Alliance Immunology Flagship
  • Victorian Clinical Genetics Services
  • Expert Review Green
OMIM
607601
Clinvar variants
Variants in TICAM1
Penetrance
None
Panels with this gene

History Filter Activity

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: TICAM1 was added gene: TICAM1 was added to Defects of innate immunity_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship Mode of inheritance for gene: TICAM1 was set to Unknown