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  3. OAS2
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Defects of intrinsic and innate immunity

Gene: OAS2

Green List (high evidence)
OAS2 (2'-5'-oligoadenylate synthetase 2)
EnsemblGeneIds (GRCh38): ENSG00000111335
EnsemblGeneIds (GRCh37): ENSG00000111335
OMIM: 603350, Gene2Phenotype
OAS2 is in 3 panels

2 reviews

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Functional data.
Created: 2 Aug 2024, 1:43 a.m. | Last Modified: 2 Aug 2024, 1:43 a.m.
Panel Version: 0.122

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Multisystem inflammatory syndrome, MONDO:0035375, OAS2-related

Publications

Created: 2 Aug 2024, 1:43 a.m.
Last Modified: 2 Aug 2024, 1:43 a.m.
Panel version: Imported from Susceptibility to Viral Infections panel version 0.122

Peter McNaughton (Queensland Children's Hospital)

Green List (high evidence)

3x unrelated patients with MIS-C after COVID infection. Patients displayed excessive inflammatory responses to intracellular dsRNA, SARS-CoV-2, SARS-CoV-2–infected cells, and their RNA, providing a plausible mechanism for MIS-C. Similar presentation to OAS1 and RNASEL.
Sources: Literature
Created: 29 Jul 2024, 5:18 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
MIS-C

Publications

Created: 29 Jul 2024, 5:18 a.m.

Panel version: Imported from Susceptibility to Viral Infections panel version 0.117

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
  • Expert Review Green
Phenotypes
  • Multisystem inflammatory syndrome, MONDO:0035375, OAS2-related
OMIM
603350
Clinvar variants
Variants in OAS2
Penetrance
None
Publications
Panels with this gene

History Filter Activity

16 Dec 2024, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: oas2 has been classified as Green List (High Evidence).

16 Dec 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: OAS2 was added gene: OAS2 was added to Defects of innate immunity. Sources: Expert list Mode of inheritance for gene: OAS2 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: OAS2 were set to 36538032 Phenotypes for gene: OAS2 were set to Multisystem inflammatory syndrome, MONDO:0035375, OAS2-related