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  2. Defects of intrinsic and innate immunity
  3. IRF9
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Defects of intrinsic and innate immunity

Gene: IRF9

Amber List (moderate evidence)
IRF9 (interferon regulatory factor 9)
EnsemblGeneIds (GRCh38): ENSG00000213928
EnsemblGeneIds (GRCh37): ENSG00000213928
OMIM: 147574, Gene2Phenotype
IRF9 is in 3 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

I don't know

Two families reported.
Sources: Expert list
Created: 5 Apr 2020, 7:37 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Immunodeficiency 65, susceptibility to viral infections 618648

Publications

Created: 5 Apr 2020, 7:37 a.m.

Panel version: Imported from Susceptibility to Viral Infections panel version 0.9

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Expert list
  • Expert Review Amber
  • Expert list
Phenotypes
  • immunodeficiency 65, susceptibility to viral infections MONDO:0032848
OMIM
147574
Clinvar variants
Variants in IRF9
Penetrance
None
Publications
Panels with this gene

History Filter Activity

15 Dec 2024, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: irf9 has been classified as Amber List (Moderate Evidence).

15 Dec 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: IRF9 was added gene: IRF9 was added to Defects of innate immunity. Sources: Expert list Mode of inheritance for gene: IRF9 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: IRF9 were set to 30826365; 30143481 Phenotypes for gene: IRF9 were set to immunodeficiency 65, susceptibility to viral infections MONDO:0032848