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  2. Defects of intrinsic and innate immunity
  3. IRF7
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Defects of intrinsic and innate immunity

Gene: IRF7

Green List (high evidence)
IRF7 (interferon regulatory factor 7)
EnsemblGeneIds (GRCh38): ENSG00000185507
EnsemblGeneIds (GRCh37): ENSG00000185507
OMIM: 605047, Gene2Phenotype
IRF7 is in 3 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Additional individuals reported PMIDs 35986347, 35670811: total of 7
Created: 6 Dec 2022, 10:03 a.m. | Last Modified: 6 Dec 2022, 10:03 a.m.
Panel Version: 0.126
Single individual and some functional data.
Created: 10 Apr 2020, 10:05 a.m. | Last Modified: 10 Apr 2020, 10:05 a.m.
Panel Version: 0.29

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Immunodeficiency 39, MIM# 616345

Publications

Created: 10 Apr 2020, 10:05 a.m.
Last Modified: 10 Apr 2020, 10:05 a.m.
Panel version: 0.126

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Melbourne Genomics Health Alliance Immunology Flagship
  • Victorian Clinical Genetics Services
Phenotypes
  • Immunodeficiency 39, MIM# 616345
OMIM
605047
Clinvar variants
Variants in IRF7
Penetrance
None
Publications
Panels with this gene

History Filter Activity

6 Dec 2022, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: irf7 has been classified as Green List (High Evidence).

10 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: irf7 has been classified as Amber List (Moderate Evidence).

10 Apr 2020, Gel status: 2

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: IRF7 were changed from to Immunodeficiency 39, MIM# 616345

10 Apr 2020, Gel status: 2

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: IRF7 were set to

10 Apr 2020, Gel status: 2

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: IRF7 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

10 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: irf7 has been classified as Amber List (Moderate Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: IRF7 was added gene: IRF7 was added to Defects of innate immunity_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship Mode of inheritance for gene: IRF7 was set to Unknown