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  2. Defects of intrinsic and innate immunity
  3. IRF3
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Defects of intrinsic and innate immunity

Gene: IRF3

Amber List (moderate evidence)
IRF3 (interferon regulatory factor 3)
EnsemblGeneIds (GRCh38): ENSG00000126456
EnsemblGeneIds (GRCh37): ENSG00000126456
OMIM: 603734, Gene2Phenotype
IRF3 is in 3 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

I don't know

Two affected individuals reported, reduced penetrance, mouse model.
Sources: Expert list
Created: 9 Jan 2020, 10:55 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
{Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7}, MIM# 616532

Publications

Created: 9 Jan 2020, 10:55 p.m.

Panel version: Imported from Susceptibility to Viral Infections panel version 0.3

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
  • Expert list
  • Expert Review Amber
  • Expert list
Phenotypes
  • encephalitis, acute, infection-induced, susceptibility to MONDO:0800174
OMIM
603734
Clinvar variants
Variants in IRF3
Penetrance
None
Publications
Panels with this gene

History Filter Activity

16 Dec 2024, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: irf3 has been classified as Amber List (Moderate Evidence).

16 Dec 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: IRF3 was added gene: IRF3 was added to Defects of innate immunity. Sources: Expert list Mode of inheritance for gene: IRF3 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: IRF3 were set to 26216125; 20660188; 26513235 Phenotypes for gene: IRF3 were set to encephalitis, acute, infection-induced, susceptibility to MONDO:0800174