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  2. Defects of intrinsic and innate immunity
  3. IFNG
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Defects of intrinsic and innate immunity

Gene: IFNG

Amber List (moderate evidence)
IFNG (interferon gamma)
EnsemblGeneIds (GRCh38): ENSG00000111537
EnsemblGeneIds (GRCh37): ENSG00000111537
OMIM: 147570, Gene2Phenotype
IFNG is in 2 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

I don't know

Now 2 unrelated homozygous cases reported with some supporting functional assays.
Sources: Expert list
Created: 16 Dec 2024, 6:12 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
inherited susceptibility to mycobacterial diseases MONDO:0019146

Publications

Created: 16 Dec 2024, 6:12 a.m.

Panel version: 1.5

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Expert list
Phenotypes
  • inherited susceptibility to mycobacterial diseases MONDO:0019146
OMIM
147570
Clinvar variants
Variants in IFNG
Penetrance
None
Publications
Panels with this gene

History Filter Activity

16 Dec 2024, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: ifng has been classified as Amber List (Moderate Evidence).

16 Dec 2024, Gel status: 2

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: ifng has been classified as Amber List (Moderate Evidence).

16 Dec 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: IFNG was added gene: IFNG was added to Defects of innate immunity. Sources: Expert list Mode of inheritance for gene: IFNG was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: IFNG were set to 32163377; 38363432 Phenotypes for gene: IFNG were set to inherited susceptibility to mycobacterial diseases MONDO:0019146 Review for gene: IFNG was set to AMBER