Defects of intrinsic and innate immunity
Gene: APOL1Comment on list classification: Included on the IUIS inborn errors of immunityCreated: 9 Nov 2024, 7:27 a.m. | Last Modified: 9 Nov 2024, 7:27 a.m.
Panel Version: 0.140
Polymorphisms enriched in the African population are associated with increased protection from trypanosomiasis but also elevated risk of FSGS. Not a monogenic disorder as such.Created: 9 Apr 2020, 12:53 a.m. | Last Modified: 9 Apr 2020, 12:53 a.m.
Panel Version: 0.18
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
{Glomerulosclerosis, focal segmental, 4, susceptibility to} 612551
Publications
Gene: apol1 has been classified as Red List (Low Evidence).
Gene: apol1 has been classified as Red List (Low Evidence).
Phenotypes for gene: APOL1 were changed from to {Glomerulosclerosis, focal segmental, 4, susceptibility to} 612551
Mode of inheritance for gene: APOL1 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Gene: apol1 has been classified as Red List (Low Evidence).
gene: APOL1 was added gene: APOL1 was added to Defects of innate immunity_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship Mode of inheritance for gene: APOL1 was set to Unknown