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  2. Disorders of immune dysregulation
  3. RHOG
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Disorders of immune dysregulation

Gene: RHOG

Amber List (moderate evidence)
RHOG (ras homolog family member G)
EnsemblGeneIds (GRCh38): ENSG00000177105
EnsemblGeneIds (GRCh37): ENSG00000177105
OMIM: 179505, Gene2Phenotype
RHOG is in 2 panels

2 reviews

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

I don't know

Good supportive functional data.
Created: 13 Jul 2022, 9:14 a.m. | Last Modified: 13 Jul 2022, 9:14 a.m.
Panel Version: 0.143

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Genetic HLH, MONDO:0015541, RHOG-related

Created: 13 Jul 2022, 9:14 a.m.
Last Modified: 13 Jul 2022, 9:14 a.m.
Panel version: 0.143

Peter McNaughton (Queensland Children's Hospital)

Red List (low evidence)

Single patient with supportive functional data.
Sources: Literature
Created: 12 Jul 2022, 6:17 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
HLH

Publications

Created: 12 Jul 2022, 6:17 a.m.

Panel version: 0.143

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
Phenotypes
  • Genetic HLH, MONDO:0015541, RHOG-related
OMIM
179505
Clinvar variants
Variants in RHOG
Penetrance
None
Publications
Panels with this gene

History Filter Activity

13 Jul 2022, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: rhog has been classified as Amber List (Moderate Evidence).

13 Jul 2022, Gel status: 2

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: RHOG were changed from HLH to Genetic HLH, MONDO:0015541, RHOG-related

13 Jul 2022, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: rhog has been classified as Amber List (Moderate Evidence).

12 Jul 2022, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Peter McNaughton (Queensland Children's Hospital)

gene: RHOG was added gene: RHOG was added to Disorders of immune dysregulation. Sources: Literature Mode of inheritance for gene: RHOG was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: RHOG were set to PMID: 33513601 Phenotypes for gene: RHOG were set to HLH Review for gene: RHOG was set to RED