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  2. Disorders of immune dysregulation
  3. IL10
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Disorders of immune dysregulation

Gene: IL10

Green List (high evidence)
IL10 (interleukin 10)
EnsemblGeneIds (GRCh38): ENSG00000136634
EnsemblGeneIds (GRCh37): ENSG00000136634
OMIM: 124092, Gene2Phenotype
IL10 is in 6 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

At least two families and a mouse model.

Rare variants in this gene are also associated with susceptibility to a range of immune-related complex disorders.
Created: 17 Mar 2022, 8:39 p.m. | Last Modified: 17 Mar 2022, 8:41 p.m.
Panel Version: 0.11523

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Diseases of Immune Dysregulation; Early-onset inflammatory bowel disease

Publications

Created: 17 Mar 2022, 8:39 p.m.
Last Modified: 17 Mar 2022, 8:41 p.m.
Panel version: Imported from Mendeliome panel version 0.11520

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Green
  • Melbourne Genomics Health Alliance Immunology Flagship
  • Victorian Clinical Genetics Services
  • Expert Review Green
  • Victorian Clinical Genetics Services
OMIM
124092
Clinvar variants
Variants in IL10
Penetrance
None
Panels with this gene

History Filter Activity

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: IL10 was added gene: IL10 was added to Disorders of immune dysregulation_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship Mode of inheritance for gene: IL10 was set to Unknown