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  2. Common Variable Immunodeficiency
  3. ICOSLG
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Common Variable Immunodeficiency

Gene: ICOSLG

Amber List (moderate evidence)
ICOSLG (inducible T-cell costimulator ligand)
EnsemblGeneIds (GRCh38): ENSG00000160223
EnsemblGeneIds (GRCh37): ENSG00000160223
OMIM: 605717, Gene2Phenotype
ICOSLG is in 3 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

I don't know

One, possibly two, reports (one not in English), some functional data.
Created: 6 Apr 2020, 8 a.m. | Last Modified: 6 Apr 2020, 8 a.m.
Panel Version: 0.5

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Immunodeficiency 119, MIM# 620825; Combined immunodeficiency; recurrent bacterial and viral infections; neutropaenia

Publications

Created: 6 Apr 2020, 8 a.m.
Last Modified: 6 Apr 2020, 8 a.m.
Panel version: 1.12

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Melbourne Genomics Health Alliance Immunology Flagship
  • Victorian Clinical Genetics Services
Phenotypes
  • Combined immunodeficiency
  • recurrent bacterial and viral infections
  • neutropaenia
OMIM
605717
Clinvar variants
Variants in ICOSLG
Penetrance
None
Publications
Panels with this gene

History Filter Activity

6 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: icoslg has been classified as Amber List (Moderate Evidence).

6 Apr 2020, Gel status: 2

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: ICOSLG were changed from to Combined immunodeficiency; recurrent bacterial and viral infections; neutropaenia

6 Apr 2020, Gel status: 2

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: ICOSLG were set to

6 Apr 2020, Gel status: 2

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: ICOSLG was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

6 Apr 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: icoslg has been classified as Amber List (Moderate Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: ICOSLG was added gene: ICOSLG was added to Common Variable Immunodeficiency_MGHA_AGHA_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship Mode of inheritance for gene: ICOSLG was set to Unknown