Combined Immunodeficiency

Gene: MOGS

Green List (high evidence)

MOGS (mannosyl-oligosaccharide glucosidase)
EnsemblGeneIds (GRCh38): ENSG00000115275
EnsemblGeneIds (GRCh37): ENSG00000115275
OMIM: 601336, Gene2Phenotype
MOGS is in 13 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Three families reported.
Sources: Expert list
Created: 3 Apr 2020, 8:52 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Congenital disorder of glycosylation, type IIb, MIM# 606056; Severe hypogammaglobulinaemia; Bacterial and viral infections; Severe neurologic disease

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Congenital disorder of glycosylation, type IIb, MIM# 606056
  • Severe hypogammaglobulinaemia
  • Bacterial and viral infections
  • Severe neurologic disease
OMIM
601336
Clinvar variants
Variants in MOGS
Penetrance
None
Publications
Panels with this gene

History Filter Activity

3 Apr 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: mogs has been classified as Green List (High Evidence).

3 Apr 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: mogs has been classified as Green List (High Evidence).

3 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: MOGS was added gene: MOGS was added to Combined Immunodeficiency. Sources: Expert list Mode of inheritance for gene: MOGS was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: MOGS were set to 10788335; 24716661; 29235540 Phenotypes for gene: MOGS were set to Congenital disorder of glycosylation, type IIb, MIM# 606056; Severe hypogammaglobulinaemia; Bacterial and viral infections; Severe neurologic disease Review for gene: MOGS was set to GREEN