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  3. INO80
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Predominantly Antibody Deficiency

Gene: INO80

Amber List (moderate evidence)
INO80 (INO80 complex subunit)
EnsemblGeneIds (GRCh38): ENSG00000128908
EnsemblGeneIds (GRCh37): ENSG00000128908
OMIM: 610169, Gene2Phenotype
INO80 is in 2 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

I don't know

Two unrelated individuals reported with some supportive functional data.
Created: 16 Mar 2022, 5:09 a.m. | Last Modified: 16 Mar 2022, 5:09 a.m.
Panel Version: 0.98

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Primary immunodeficiency, MONDO:0003778

Publications

Created: 16 Mar 2022, 5:09 a.m.
Last Modified: 16 Mar 2022, 5:09 a.m.
Panel version: 0.98

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
  • Melbourne Genomics Health Alliance Immunology Flagship
  • Victorian Clinical Genetics Services
Phenotypes
  • Primary immunodeficiency, MONDO:0003778
OMIM
610169
Clinvar variants
Variants in INO80
Penetrance
None
Publications
Panels with this gene

History Filter Activity

16 Mar 2022, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ino80 has been classified as Amber List (Moderate Evidence).

16 Mar 2022, Gel status: 2

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: INO80 were changed from to Primary immunodeficiency, MONDO:0003778

16 Mar 2022, Gel status: 2

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: INO80 were set to

16 Mar 2022, Gel status: 2

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: INO80 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

16 Mar 2022, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: ino80 has been classified as Amber List (Moderate Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: INO80 was added gene: INO80 was added to Predominantly antibody deficiency_MelbourneGenomics_AustralianGenomics_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Immunology Flagship Mode of inheritance for gene: INO80 was set to Unknown