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  2. Atypical Haemolytic Uraemic Syndrome_MPGN
  3. VTN
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Atypical Haemolytic Uraemic Syndrome_MPGN

Gene: VTN

Red List (low evidence)
VTN (vitronectin)
EnsemblGeneIds (GRCh38): ENSG00000109072
EnsemblGeneIds (GRCh37): ENSG00000109072
OMIM: 193190, Gene2Phenotype
VTN is in 2 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

I don't know

Comment when marking as ready: Downgraded to Red after review against Genomics England panel.
Created: 9 Jan 2020, 10:06 a.m. | Last Modified: 9 Jan 2020, 10:06 a.m.
Panel Version: 0.20
Over-representation in cases vs controls but no functional data and mechanism unclear at present.
Created: 20 Nov 2019, 5:39 a.m. | Last Modified: 20 Nov 2019, 5:39 a.m.
Panel Version: 0.4

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Atypical haemolytic uraemic syndrome

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 18 Nov 2019, 5:38 a.m.
Last Modified: 18 Nov 2019, 5:38 a.m.
Panel version: 0.4

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Red
  • Victorian Clinical Genetics Services
Phenotypes
  • Atypical haemolytic uraemic syndrome
OMIM
193190
Clinvar variants
Variants in VTN
Penetrance
None
Publications
Panels with this gene

History Filter Activity

9 Jan 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: vtn has been classified as Red List (Low Evidence).

9 Jan 2020, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: VTN were changed from to Atypical haemolytic uraemic syndrome

9 Jan 2020, Gel status: 1

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: VTN were set to

9 Jan 2020, Gel status: 1

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: VTN was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

9 Jan 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: vtn has been classified as Red List (Low Evidence).

20 Nov 2019, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: vtn has been classified as Amber List (Moderate Evidence).

20 Nov 2019, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: vtn has been classified as Amber List (Moderate Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: VTN was added gene: VTN was added to Atypical Haemolytic Uraemic Syndrome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: VTN was set to Unknown