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Atrial Fibrillation
Gene: KCNE5

KCNE5 (potassium voltage-gated channel subfamily E regulatory subunit 5)
EnsemblGeneIds (GRCh38): ENSG00000176076
EnsemblGeneIds (GRCh37): ENSG00000176076
OMIM: 300328, Gene2Phenotype
KCNE5 is in 4 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Association with Brugada is DISPUTED. Rare variants in KCNE5 reported in AF cohorts with some supportive functional data.
Created: 14 Mar 2022, 6:36 a.m. | Last Modified: 14 Mar 2022, 6:36 a.m.

Panel Version: 0.7

Mode of inheritance
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Phenotypes
Atrial fibrillation

Publications

Created: 14 Mar 2022, 6:36 a.m.
Last Modified: 14 Mar 2022, 6:36 a.m.
Panel version: 0.7

Details

Mode of Inheritance

X-LINKED: hemizygous mutation in males, biallelic mutations in females

Sources

Expert Review Red
Victorian Clinical Genetics Services

Phenotypes

Atrial fibrillation

OMIM

Clinvar variants

Variants in KCNE5

Penetrance

None

Publications

Panels with this gene

History Filter Activity

14 Mar 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: kcne5 has been classified as Red List (Low Evidence).

14 Mar 2022, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: KCNE5 were changed from Atrial fibrillation to Atrial fibrillation

14 Mar 2022, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: KCNE5 were changed from to Atrial fibrillation

14 Mar 2022, Gel status: 1

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: KCNE5 were set to

14 Mar 2022, Gel status: 1

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: KCNE5 was changed from Unknown to X-LINKED: hemizygous mutation in males, biallelic mutations in females

14 Mar 2022, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: kcne5 has been classified as Red List (Low Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: KCNE5 was added gene: KCNE5 was added to Atrial fibrilation_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: KCNE5 was set to Unknown