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  3. TNC
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Deafness_IsolatedAndComplex

Gene: TNC

Amber List (moderate evidence)
TNC (tenascin C)
EnsemblGeneIds (GRCh38): ENSG00000041982
EnsemblGeneIds (GRCh37): ENSG00000041982
OMIM: 187380, Gene2Phenotype
TNC is in 3 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

I don't know

Two unrelated families reported.
Created: 2 Jan 2020, 5:46 a.m. | Last Modified: 2 Jan 2020, 5:46 a.m.
Panel Version: 0.214

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Deafness, autosomal dominant 56, MIM# 615629

Publications

Created: 2 Jan 2020, 5:46 a.m.
Last Modified: 2 Jan 2020, 5:46 a.m.
Panel version: 0.214

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
  • Melbourne Genomics Health Alliance Deafness Flagship
  • Victorian Clinical Genetics Services
Phenotypes
  • Deafness, autosomal dominant 56, MIM# 615629
OMIM
187380
Clinvar variants
Variants in TNC
Penetrance
None
Publications
Panels with this gene

History Filter Activity

2 Jan 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: tnc has been classified as Amber List (Moderate Evidence).

2 Jan 2020, Gel status: 2

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: TNC were changed from to Deafness, autosomal dominant 56, MIM# 615629

2 Jan 2020, Gel status: 2

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: TNC were set to

2 Jan 2020, Gel status: 2

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: TNC was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

2 Jan 2020, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: tnc has been classified as Amber List (Moderate Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: TNC was added gene: TNC was added to Deafness_MelbourneGenomics_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services,Melbourne Genomics Health Alliance Deafness Flagship Mode of inheritance for gene: TNC was set to Unknown