Calcium and Phosphate disorders

Gene: NRAS

Green List (high evidence)

NRAS (NRAS proto-oncogene, GTPase)
EnsemblGeneIds (GRCh38): ENSG00000213281
EnsemblGeneIds (GRCh37): ENSG00000213281
OMIM: 164790, Gene2Phenotype
NRAS is in 18 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

Green List (high evidence)

5 cases with cutaneous skeletal hypophosphatemia syndrome and all with somatic mosaic activating NRAS Q61R
Sources: Literature
Created: 1 Apr 2024, 4:52 a.m.

Mode of inheritance
Other

Phenotypes
Costello syndrome MONDO:0009026

Publications

Mode of pathogenicity
Other

Variants in this GENE are reported as part of current diagnostic practice

History Filter Activity

1 Apr 2024, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: nras has been classified as Green List (High Evidence).

1 Apr 2024, Gel status: 3

Entity classified by Genomics England curator

Bryony Thompson (Royal Melbourne Hospital)

Gene: nras has been classified as Green List (High Evidence).

1 Apr 2024, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set mode of pathogenicity

Bryony Thompson (Royal Melbourne Hospital)

gene: NRAS was added gene: NRAS was added to Calcium and Phosphate disorders. Sources: Literature Mode of inheritance for gene: NRAS was set to Other Publications for gene: NRAS were set to 24006476; 35999193; 32157705; 27900779 Phenotypes for gene: NRAS were set to Costello syndrome MONDO:0009026 Mode of pathogenicity for gene: NRAS was set to Other Review for gene: NRAS was set to GREEN gene: NRAS was marked as current diagnostic