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  3. LAMC3
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Polymicrogyria and Schizencephaly

Gene: LAMC3

Green List (high evidence)
LAMC3 (laminin subunit gamma 3)
EnsemblGeneIds (GRCh38): ENSG00000050555
EnsemblGeneIds (GRCh37): ENSG00000050555
OMIM: 604349, Gene2Phenotype
LAMC3 is in 8 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

>3 unrelated families reported
Created: 25 Mar 2022, 3:02 a.m. | Last Modified: 25 Mar 2022, 3:02 a.m.
Panel Version: 0.172

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Cortical malformations, occipital, MIM#614115

Publications

Created: 25 Mar 2022, 3:02 a.m.
Last Modified: 25 Mar 2022, 3:02 a.m.
Panel version: 0.172

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
  • Australian Genomics Health Alliance Brain Malformations Flagship
Phenotypes
  • Cortical malformations, occipital, MIM#614115
OMIM
604349
Clinvar variants
Variants in LAMC3
Penetrance
None
Publications
Panels with this gene

History Filter Activity

25 Mar 2022, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: lamc3 has been classified as Green List (High Evidence).

25 Mar 2022, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: LAMC3 were changed from to Cortical malformations, occipital, MIM#614115

25 Mar 2022, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: LAMC3 were set to

25 Mar 2022, Gel status: 3

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: LAMC3 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: LAMC3 was added gene: LAMC3 was added to Polymicrogyria and schizencephaly_AustralianGenomics_VCGS. Sources: Australian Genomics Health Alliance Brain Malformations Flagship,Victorian Clinical Genetics Services,Expert Review Green Mode of inheritance for gene: LAMC3 was set to Unknown