Rasopathy
Gene: KRAS

KRAS (KRAS proto-oncogene, GTPase)
EnsemblGeneIds (GRCh38): ENSG00000133703
EnsemblGeneIds (GRCh37): ENSG00000133703
OMIM: 190070, Gene2Phenotype
KRAS is in 21 panels

2 reviews

Chirag Patel (Genetic Health Queensland)

GOF variants.
Created: 26 Sep 2024, 4:49 a.m. | Last Modified: 26 Sep 2024, 4:49 a.m.

Panel Version: 0.105

Mode of pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments

Created: 26 Sep 2024, 4:49 a.m.
Last Modified: 26 Sep 2024, 4:49 a.m.
Panel version: 0.105

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

Well established gene-disease association in individuals with Noonan syndrome, CFC and overlapping Noonan-CFC.
Created: 11 Sep 2020, 10:22 a.m. | Last Modified: 11 Sep 2020, 10:22 a.m.

Panel Version: 0.44

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Noonan syndrome 3, MIM# 609942; Cardiofaciocutaneous syndrome 2, MIM# 615278

Publications

Created: 11 Sep 2020, 10:22 a.m.
Last Modified: 11 Sep 2020, 10:22 a.m.
Panel version: 0.47

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Sources

Expert Review Green
Victorian Clinical Genetics Services

Phenotypes

Noonan syndrome 3, MIM# 609942
Cardiofaciocutaneous syndrome 2, MIM# 615278

OMIM

190070

Clinvar variants

Variants in KRAS

Penetrance

None

Publications

Mode of Pathogenicity

Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments

Panels with this gene