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  3. NYNRIN
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Cancer Predisposition_Paediatric

Gene: NYNRIN

Amber List (moderate evidence)
NYNRIN (NYN domain and retroviral integrase containing)
EnsemblGeneIds (GRCh38): ENSG00000205978
EnsemblGeneIds (GRCh37): ENSG00000205978
NYNRIN is in 3 panels

1 review

Laura Raiti (Royal Children's Hospital, Melbourne)

I don't know

3 individuals with Wilms Tumour reported (2 children from 1 family, the 3rd child from a second family).
Biallelic truncating mutations in NYNRIN in three children with Wilms Tumour from two families, each parent was heterozygous for one of the mutations.
One of the affected children had an inguinal hernia and another had epilepsy, hypothyroidism, and intellectual disability.
Sources: Literature
Created: 11 Jul 2021, 5:56 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Publications

Created: 11 Jul 2021, 5:56 a.m.

Panel version: 0.101

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
Phenotypes
  • Wilms tumour predisposition
Clinvar variants
Variants in NYNRIN
Penetrance
None
Publications
Panels with this gene

History Filter Activity

11 Jul 2021, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: nynrin has been classified as Amber List (Moderate Evidence).

11 Jul 2021, Gel status: 2

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: NYNRIN were changed from to Wilms tumour predisposition

11 Jul 2021, Gel status: 2

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: nynrin has been classified as Amber List (Moderate Evidence).

11 Jul 2021, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications

Laura Raiti (Royal Children's Hospital, Melbourne)

gene: NYNRIN was added gene: NYNRIN was added to Cancer Predisposition_Paediatric. Sources: Literature Mode of inheritance for gene: NYNRIN was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: NYNRIN were set to PMID: 30885698 Review for gene: NYNRIN was set to AMBER