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  2. Cancer Predisposition_Paediatric
  3. GPR161
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Cancer Predisposition_Paediatric

Gene: GPR161

Green List (high evidence)
GPR161 (G protein-coupled receptor 161)
EnsemblGeneIds (GRCh38): ENSG00000143147
EnsemblGeneIds (GRCh37): ENSG00000143147
OMIM: 612250, Gene2Phenotype
GPR161 is in 6 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Green List (high evidence)

6 unrelated individuals reported with germline variants, 5 with truncating, one missense. Somatic second hit in tumour tissue.
Sources: Literature
Created: 6 Jul 2020, 1:38 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Predisposition to paediatric medulloblastoma

Publications

Created: 6 Jul 2020, 1:38 a.m.

Panel version: 0.13

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Literature
Phenotypes
  • Predisposition to paediatric medulloblastoma
OMIM
612250
Clinvar variants
Variants in GPR161
Penetrance
None
Publications
Panels with this gene

History Filter Activity

6 Jul 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: gpr161 has been classified as Green List (High Evidence).

6 Jul 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: gpr161 has been classified as Green List (High Evidence).

6 Jul 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: GPR161 was added gene: GPR161 was added to Cancer Predisposition_Paediatric. Sources: Literature Mode of inheritance for gene: GPR161 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: GPR161 were set to 31609649 Phenotypes for gene: GPR161 were set to Predisposition to paediatric medulloblastoma Review for gene: GPR161 was set to GREEN