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  3. CDK4
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Cancer Predisposition_Paediatric

Gene: CDK4

Red List (low evidence)
CDK4 (cyclin dependent kinase 4)
EnsemblGeneIds (GRCh38): ENSG00000135446
EnsemblGeneIds (GRCh37): ENSG00000135446
OMIM: 123829, Gene2Phenotype
CDK4 is in 5 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Not generally childhood onset.
Created: 1 Aug 2020, 7:23 a.m. | Last Modified: 1 Aug 2020, 7:23 a.m.
Panel Version: 0.32

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
{Melanoma, cutaneous malignant, 3}, MIM# 609048

Created: 1 Aug 2020, 7:23 a.m.
Last Modified: 1 Aug 2020, 7:23 a.m.
Panel version: 0.32

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Red
  • Victorian Clinical Genetics Services
Phenotypes
  • {Melanoma, cutaneous malignant, 3}, MIM# 609048
OMIM
123829
Clinvar variants
Variants in CDK4
Penetrance
None
Panels with this gene

History Filter Activity

1 Aug 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: cdk4 has been classified as Red List (Low Evidence).

1 Aug 2020, Gel status: 1

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: CDK4 were changed from to {Melanoma, cutaneous malignant, 3}, MIM# 609048

1 Aug 2020, Gel status: 1

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: CDK4 was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

1 Aug 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: cdk4 has been classified as Red List (Low Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: CDK4 was added gene: CDK4 was added to Paediatric Cancer Predisposition_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: CDK4 was set to Unknown