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  3. WNT10A
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Oligodontia

Gene: WNT10A

Green List (high evidence)
WNT10A (Wnt family member 10A)
EnsemblGeneIds (GRCh38): ENSG00000135925
EnsemblGeneIds (GRCh37): ENSG00000135925
OMIM: 606268, Gene2Phenotype
WNT10A is in 6 panels

2 reviews

Michelle Torres (Victorian Clinical Genetics Services)

Green List (high evidence)

Genotype-phenotype correlation is unclear. The same variant has been associated with all 3 phenotypes and both AR and AD inheritance. Variable expressivity, however milder phenotypes seem to be associated with AD (PMID: 19559398; 30426266)
Created: 8 May 2020, 2:43 a.m. | Last Modified: 8 May 2020, 2:43 a.m.
Panel Version: 0.1

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
Odontoonychodermal dysplasia 257980 AR; Schopf-Schulz-Passarge syndrome 224750 AR; Tooth agenesis, selective, 4 150400 AR, AD

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 8 May 2020, 2:43 a.m.
Last Modified: 8 May 2020, 2:43 a.m.
Panel version: 0.1

Elena Savva (Victorian Clinical Genetics Services)

Green List (high evidence)

Appears to be fully penetrant in PTC homozygotes, however missense compound heterozygotes and heterozygote carriers may be unaffected, or display only some phenotypic manifestation
Created: 7 Feb 2020, 4:50 a.m. | Last Modified: 7 Feb 2020, 4:50 a.m.
Panel Version: 0.1285

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
Odontoonychodermal dysplasia; Schopf-Schulz-Passarge syndrome; Tooth agenesis, selective, 4

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 7 Feb 2020, 4:50 a.m.
Last Modified: 7 Feb 2020, 4:50 a.m.
Panel version: Imported from Mendeliome panel version 0.1285

Details

Mode of Inheritance
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Odontoonychodermal dysplasia 257980 AR
  • Schopf-Schulz-Passarge syndrome 224750 AR
  • Tooth agenesis, selective, 4 150400 AR, AD
OMIM
606268
Clinvar variants
Variants in WNT10A
Penetrance
None
Publications
Panels with this gene

History Filter Activity

8 May 2020, Gel status: 3

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: wnt10a has been classified as Green List (High Evidence).

8 May 2020, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: WNT10A were changed from to Odontoonychodermal dysplasia 257980 AR; Schopf-Schulz-Passarge syndrome 224750 AR; Tooth agenesis, selective, 4 150400 AR, AD

8 May 2020, Gel status: 3

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: WNT10A were set to

8 May 2020, Gel status: 3

Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Mode of inheritance for gene: WNT10A was changed from Unknown to BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: WNT10A was added gene: WNT10A was added to Oligodontia_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: WNT10A was set to Unknown