Osteogenesis Imperfecta and Osteoporosis

Gene: WNT4

Red List (low evidence)

WNT4 (Wnt family member 4)
EnsemblGeneIds (GRCh38): ENSG00000162552
EnsemblGeneIds (GRCh37): ENSG00000162552
OMIM: 603490, Gene2Phenotype
WNT4 is in 5 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

Red List (low evidence)

Mouse model where recombinant Wnt4 alleviated bone loss and inflammation by inhibiting NF-κB in vivo in mouse models of bone disease. However, no reported association with Mendelian disease. A common SNP (rs10917157) has been associated with bone mineral density.
Sources: Expert list
Created: 30 Aug 2021, 2:18 a.m.

Mode of inheritance
Unknown

Phenotypes
Osteoporosis

Publications

Details

History Filter Activity

30 Aug 2021, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: WNT4 was added gene: WNT4 was added to Osteogenesis Imperfecta. Sources: Expert list Mode of inheritance for gene: WNT4 was set to Unknown Publications for gene: WNT4 were set to 25108526; 26733379 Phenotypes for gene: WNT4 were set to Osteoporosis Review for gene: WNT4 was set to RED