Osteogenesis Imperfecta and Osteoporosis
Gene: WNT4

WNT4 (Wnt family member 4)
EnsemblGeneIds (GRCh38): ENSG00000162552
EnsemblGeneIds (GRCh37): ENSG00000162552
OMIM: 603490, Gene2Phenotype
WNT4 is in 5 panels

1 review

Bryony Thompson (Royal Melbourne Hospital)

Red List (low evidence)

Mouse model where recombinant Wnt4 alleviated bone loss and inflammation by inhibiting NF-κB in vivo in mouse models of bone disease. However, no reported association with Mendelian disease. A common SNP (rs10917157) has been associated with bone mineral density.
Sources: Expert list
Created: 30 Aug 2021, 2:18 a.m.

Mode of inheritance
Unknown

Phenotypes
Osteoporosis

Publications

Created: 30 Aug 2021, 2:18 a.m.

Panel version: 0.57

Details

Mode of Inheritance

Unknown

Sources

Expert list

Phenotypes

Osteoporosis

OMIM

603490

Clinvar variants

Variants in WNT4

Penetrance

None

Publications

Panels with this gene

History Filter Activity

30 Aug 2021, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Bryony Thompson (Royal Melbourne Hospital)

gene: WNT4 was added gene: WNT4 was added to Osteogenesis Imperfecta. Sources: Expert list Mode of inheritance for gene: WNT4 was set to Unknown Publications for gene: WNT4 were set to 25108526; 26733379 Phenotypes for gene: WNT4 were set to Osteoporosis Review for gene: WNT4 was set to RED

Osteogenesis Imperfecta and Osteoporosis Gene: WNT4