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Mendeliome

Gene: ZNF445

Red List (low evidence)

ZNF445 (zinc finger protein 445)
EnsemblGeneIds (GRCh38): ENSG00000185219
EnsemblGeneIds (GRCh37): ENSG00000185219
ZNF445 is in 2 panels

1 review

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Red List (low evidence)

Single report (Kagami 2021) of a child with Temple syndrome and MLID found to have a novel homozygous truncating variant in ZNF445.

ZNF445 has been shown to play a critical role in the maintenance of postfertilisation methylation imprints (Takahashi 2019). Mechanism and parent of origin effects remain uncertain.
Sources: Literature
Created: 15 Oct 2021, 8:58 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Temple syndrome; Multi locus imprinting disturbance (MLID)

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • Literature
Phenotypes
  • Temple syndrome
  • Multi locus imprinting disturbance (MLID)
Clinvar variants
Variants in ZNF445
Penetrance
None
Publications
Panels with this gene

History Filter Activity

15 Oct 2021, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: znf445 has been classified as Red List (Low Evidence).

15 Oct 2021, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: ZNF445 was added gene: ZNF445 was added to Mendeliome. Sources: Literature Mode of inheritance for gene: ZNF445 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: ZNF445 were set to 34039421; 30602440; 30846001 Phenotypes for gene: ZNF445 were set to Temple syndrome; Multi locus imprinting disturbance (MLID) Review for gene: ZNF445 was set to RED