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Mendeliome

Gene: SLC15A4

Red List (low evidence)

SLC15A4 (solute carrier family 15 member 4)
EnsemblGeneIds (GRCh38): ENSG00000139370
EnsemblGeneIds (GRCh37): ENSG00000139370
OMIM: 615806, Gene2Phenotype
SLC15A4 is in 2 panels

1 review

Naomi Baker (Victorian Clinical Genetics Services)

Red List (low evidence)

Red in Genomics England Panel App for Pituitary hormone deficiency, however not reviewed.

Unable to find any evidence of monogenic diseases associations.

PMID: 25238095 - GWAS studies suggest SLC15A4 is associated with inflammatory diseases such as type 2 diabetes (Takeuchi et al., 2008), systemic lupus erythematosus (SLE) (Han et al., 2009; He et al., 2010; Wang et al., 2012), and inflammatory bowel disease (IBD) (Lee et al., 2009).
Created: 20 May 2020, 1:38 a.m. | Last Modified: 20 May 2020, 1:38 a.m.
Panel Version: 0.2833

Publications

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • Victorian Clinical Genetics Services
OMIM
615806
Clinvar variants
Variants in SLC15A4
Penetrance
None
Publications
Panels with this gene

History Filter Activity

20 May 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: slc15a4 has been classified as Red List (Low Evidence).

20 May 2020, Gel status: 1

Set publications

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Publications for gene: SLC15A4 were set to

20 May 2020, Gel status: 1

Entity classified by Genomics England curator

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Gene: slc15a4 has been classified as Red List (Low Evidence).

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: SLC15A4 was added gene: SLC15A4 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: SLC15A4 was set to Unknown