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Mendeliome

Gene: LYZ

Green List (high evidence)

LYZ (lysozyme)
EnsemblGeneIds (GRCh38): ENSG00000090382
EnsemblGeneIds (GRCh37): ENSG00000090382
OMIM: 153450, Gene2Phenotype
LYZ is in 5 panels

2 reviews

Abhijit Kulkarni (Healius Pathology)

Green List (high evidence)

Known gene disease association
Created: 20 May 2022, 12:49 a.m. | Last Modified: 20 May 2022, 12:49 a.m.
Panel Version: 0.14662

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Amyloidosis, renal (MIM: 105200)

Publications

Krithika Murali (Victorian Clinical Genetics Services)

Green List (high evidence)

Multiple unrelated families reported. P/LP ClinVar variants predominantly from literature, one from clinical testing Mayo Laboratories. Multiple LYZ variants in Hereditary Amyloidosis database.
Created: 20 May 2022, 12:34 a.m. | Last Modified: 20 May 2022, 12:34 a.m.
Panel Version: 0.14658

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Amyloidosis, renal - MIM#105200

Publications

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Amyloidosis, renal, MIM# 105200
  • Amyloidosis, hereditary systemic 5, MIM# 620658
OMIM
153450
Clinvar variants
Variants in LYZ
Penetrance
None
Publications
Panels with this gene

History Filter Activity

22 May 2024, Gel status: 3

Set Phenotypes

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

Phenotypes for gene: LYZ were changed from Amyloidosis, renal, MIM# 105200 to Amyloidosis, renal, MIM# 105200; Amyloidosis, hereditary systemic 5, MIM# 620658

9 May 2022, Gel status: 3

Entity classified by Genomics England curator

Alison Yeung (Victorian Clinical Genetics Services)

Gene: lyz has been classified as Green List (High Evidence).

9 May 2022, Gel status: 3

Set Phenotypes

Alison Yeung (Victorian Clinical Genetics Services)

Phenotypes for gene: LYZ were changed from to Amyloidosis, renal, MIM# 105200

9 May 2022, Gel status: 3

Set publications

Alison Yeung (Victorian Clinical Genetics Services)

Publications for gene: LYZ were set to

9 May 2022, Gel status: 3

Set mode of inheritance

Alison Yeung (Victorian Clinical Genetics Services)

Mode of inheritance for gene: LYZ was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

17 Nov 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance

Zornitza Stark (Victorian Clinical Genetics Services; Australian Genomics)

gene: LYZ was added gene: LYZ was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services Mode of inheritance for gene: LYZ was set to Unknown